1Heat oven to 375°F. In 10-inch skillet, cook beef over medium-high heat 5 to 7 minutes, stirring occasionally, until thoroughly cooked; drain. Stir in ketchup; cook over medium-high heat, stirring occasionally, until hot. Stir in relish, cheese and mustard; set aside.
2Separate dough into 4 rectangles. Place on ungreased cookie sheet. Press each to 8x5-inch rectangle, firmly pressing perforations to seal. Divide beef mixture evenly among rectangles. Bring ends up over filling, overlapping about 1 inch. Press edges with fork to seal. Brush dough with water; sprinkle each with 1/4 teaspoon sesame seed.
3Bake 13 to 15 minutes or until golden brown. Immediately remove from cookie sheet.