In medium microwavable bowl, microwave caramels and water uncovered on High 1 minute; stir. Microwave 30 to 45 seconds longer, stirring every 15 seconds, until melted and smooth. Spread over cooled brownies. Immediately sprinkle crushed pretzels over caramel; sprinkle with salt. Let stand about 30 minutes to set. Cut into 4 rows by 4 rows. Store covered in refrigerator.