1Heat oven to 350°. Grease bottom and sides of rectangular baking dish, 13x9x2 inches, with shortening. Spray 10-inch skillet with cooking spray; heat over medium-high heat. Cook bell pepper and onion in skillet, stirring occasionally, until tender; remove from heat.
2Stir together Bisquick, milk, mayonnaise and eggs. Pour half of the batter into baking dish. Top with half of the beef, the bell pepper mixture and three-fourths of the cheese. Top with remaining beef. Pour remaining batter over beef.
3Bake uncovered 35 to 45 minutes or until golden brown. Top with remaining cheese. Let stand 5 minutes before cutting.