Beef mixture can be microwaved. For step 2, crumble ground beef into microwavable 2-quart casserole. Cover and microwave on High 6 minutes, stirring every 3 minutes, until no longer pink; drain. Stir in spaghetti sauce and macaroni; OMIT 3/4 cup water. Cover and microwave on High 6 minutes or until boiling; stir. Spoon Bisquick® mixture around edge of casserole, leaving center open. Continue with step 3.
Use ground turkey breast instead of the ground beef.