I make mine in my slow cooker. My family's favorite recipe is Paula Deen's. She says to wrap the roast in foil & bake for several hours. While I'm sure it would be fine that way, I prefer the slow cooker because it's just always perfectly cooked. The recipe as I cook it is as follows:
1 (3 to 4-pound) boneless chuck roast
11/2 teaspoon salt
1 teaspoon black pepper
1/2 tsp garlic powder
2 tablespoons vegetable oil
1 cup thinly sliced onion wedges
3 cloves garlic, crushed
2 bay leaves
1 (10 3/4-ounce) can cream of mushroom soup
1/4 cup red wine
2 tablespoons Worcestershire sauce
1 tablespoon beef bouillon granules
3/4 cup water
Mix the salt, pepper & garlic powder and rub onto all sides of your roast. Heat oil in a heavy skillet. Sear the roast on both sides for only a couple of minutes each side. Remove roast and place in slow cooker.
Sautee garlic & onions in left over oil in skillet for 3-4 mins. Add remaining ingredient and mix to combine. Pour everything over the roast in your slow cooker. Cook on low for 7+ hours.
*We love to serve this with garlic mashed potatoes.